Lead QA Engineer

Compensation: National: $114,000-$160,000 NYC/SF: $120,000-$170,000 Tempus AI is a cutting-edge clinical laboratory coupled with powerful automation capabilities. We continually strive to deliver quality results to our patients as quickly as possible.

As a Lead QA Engineer, you will own the quality engineering strategy for a portfolio of in-house developed clinical software, including a HIPAA-compliant clinical order platform and its supporting data-query and ETL tooling, and you will be the senior-most technical voice on how we prove that software works.

You will set the test architecture and automation standards that our Senior and mid-level QA engineers build against, own nightly regression and CI/CD test orchestration end to end, and lead release readiness and go/no-go decisions with evidence rather than opinion.

Knowledge of genetic testing, molecular biology, or other scientific disciplines is a strong plus but is not required. This is a fantastic opportunity to shape how quality is engineered across a growing clinical software organization.

Key Responsibilities

Own the end-to-end quality engineering strategy across the application portfolio: test architecture, tooling selection, coverage targets.

• Set and enforce the automation framework architecture across multiple suites and repositories, reusable page objects and fixtures, shared utilities, dependency and version management, stable selectors, and act as the final reviewer on test-framework pull requests.

• Own CI/CD test orchestration end to end (GitHub Actions or equivalent): deployment-triggered and nightly regression runs, health checks, artifact and version gating, reporting, and automated notification.

• Lead release readiness and go/no-go: consolidate risk assessment, validation evidence, and quality metrics into a clear recommendation for engineering and product leadership.

• Drive shift-left across the Agile Scrum teams you support, represent quality and testability in design reviews, requirements