Job Description
Vice President, Clinical Development (Oncology & Molecular Diagnostics) Reports to: Chief Medical Officer, Corporate Location: United States (Remote, with up to 30% travel) Position Summary Natera is seeking a Vice President of Clinical Development to deliver absolute ownership over the strategy, design, and execution of Natera -sponsored clinical studies. This corporate leader will institutionalize clinical trial architecture across the enterprise, distinct from therapeutic area strategy, with an immediate focus on defending and expanding our oncology footprint (including Early Cancer Detection and Signatera MRD), alongside corporate-level support for Women's Health and Organ Health. Reporting directly to the Chief Medical Officer, you will be accountable for the operational health, scientific validity, and clinical utility data generated by Natera ’s multi-million dollar sponsored study portfolio. This is a high-autonomy role for a builder who can navigate rapid structural transitions—specifically our evolution from a Laboratory Developed Test (LDT) framework into highly regulated FDA In Vitro Diagnostic (IVD) and Companion Diagnostic (CDx) pharma partnerships. Key Responsibilities Portfolio Architecture & Governance: Establish and enforce portfolio-level governance models to monitor study health, site enrollment, milestone delivery, sample flow, and data readiness. Make definitive, data-driven go/no-go decisions on trial modifications, accelerations, or terminations based on objective strategic value and execution feasibility. Clinical Utility Design: Lead cross-functional teams to design high-impact prospective, observational, and decision-impact trials. Translate clinical questions into protocols that explicitly isolate and prove clinical validity, analytical validity, and decision-impact endpoints to secure broad commercial payer coverage and medical guideline inclusion. Regulatory & CDx Alignment: Partner with Regulatory affairs to build clinical evidence str
