Job Description
Who We Are Vial is a hyper-scalable biotech company advancing programs into the clinic by leveraging dramatically cheaper trials and computationally designed therapeutics. Our mission is to reimagine drug development in order to cure all human diseases. We have assembled a talented team of clinical operators, scientists, and innovative thinkers to achieve this vision. Vial is fully remote and was founded by Simon Burns in October 2020. Since our founding, we have grown rapidly to a team of 50+ employees with over $100 million in funding from leading investors including General Catalyst, Box Group, and Byers Capital. Vial is rebuilding the infrastructure to advance research. By deploying technology at every step, we are creating a more efficient future for drug discovery. What You'll do As a PBPK Modeler at Vial , you will play a critical role in predicting human pharmacokinetics (PK) and optimizing dosing strategies for our novel drug candidates across multiple modalities, including antibodies, small molecules, and oligonucleotides . You will work closely with cross-functional teams to integrate in vitro, preclinical, and clinical data into physiologically based pharmacokinetic (PBPK) models to support decision-making in drug development. We are looking for individuals who are deeply experienced in PBPK modeling , thrive in fast-paced environments, and can independently develop and validate models to guide clinical translation. Key Responsibilities Develop and refine PBPK models to predict human PK for novel drug candidates using available in vitro and preclinical data. Compare and validate PBPK models using published clinical PK data from reference compounds to establish model credibility. Propose clinical dosing regimens based on PBPK model outputs, leveraging reference drug data for benchmarking. Analyze and interpret model predictions , identifying key parameters influencing drug exposure and clearance. Collaborate with internal scientists and external partners
