Job Description
Project Overview SMART CAMP (Critical Analytics for Manufacturing Personalized-Medicine) is an interdisciplinary research programme in Singapore (CREATE international research campus and innovation hub) and at the Massachusetts Institute of Technology (MIT). SMART CAMP addresses key technology bottlenecks in cell therapy manufacturing: (i) critical quality attributes (CQA) of safe, effective cell therapy products; and (ii) integrated process analytics to monitor and modulate those attributes. Our efforts are focused on allogeneic and autologous cell therapy products, including but not limited to cell sources including adult stem/progenitor cells and immune cells for treatment of specific cancers, tissue degeneration, and autoimmune diseases. This interdisciplinary team comprises engineers, biologists, clinicians, manufacturing, and data analytics experts from multiple MIT academic units, and multiple Singapore-based universities, research centres of excellence, and hospitals who are experienced at translational demonstrations of technologies in safety-regulated industries such as cell therapies. SMART, MIT’s first such research unit outside of Cambridge, MA, serves as an intellectual hub, allowing faculty, researchers and graduate students from MIT to collaborate with their academic and industrial counterparts from Singapore and the region in exciting new areas of science and technology. Responsibilities Process analytic technologies (PAT) for cell therapy manufacturing must be accessible to or integrated with the culture vessels in which the cells are expanded to sufficient cell number and quality. This can be especially challenging for adherent cell types, for which production scaleup includes cell adhesion to microcarrier beads and subsequent removal from those surfaces for most types of cell therapy product administration. This PDA will focus on therapeutic applications of IPSCs and the means for improving their efficacy through process optimization in an automa
